Factory Supply Dihexa CAS 1401708-83-5 as Brain Health Supplements

• Customization: Available
• CAS No.: 1401708-83-5
• Formula: C27h44n4o5
• Model NO.: Worldyang
• EINECS: 227-005-2
• Environmental Protection: Yes
• Certification: ISO9001
• Color: White
• Classification: Neurotoxin
• Function: Keeping Health and Promoting Growth
• Appearance: Powder
• Melting Point: 209 Celsius Degree
• Pka: 9.83
• Storage: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Density: 1.111
• Transport Package: as Required
• Specification: 99%+
• Trademark: Worldyang
• Origin: China
• HS Code: 2933790099

Product Description

Product Name: Dihexa
CAS Number: 1401708-83-5
Appearance: White Powder
Purity: 99%

Product Description:

Dihexa (PNB-0408) is a synthetic oligopeptide and angiotensin IV analog with remarkable bioactivity, including oral availability and blood-brain barrier permeability. It demonstrates high-affinity binding to hepatocyte growth factor (HGF) with a dissociation constant (Kd) of 65 pM, significantly enhancing HGF's activity on its receptor, c-Met. Preclinical studies have shown Dihexa's potential in improving cognitive function and exhibiting antipsychotic effects, making it a promising candidate for Alzheimer's disease research.

Biological Activity:

• Target Affinity: High-affinity binding to HGF (Kd: 65 pM).
• Mechanism: Enhances c-Met activation through HGF-dependent mechanisms, promoting synaptogenesis and spinogenesis in hippocampal neurons.
• In Vitro Studies:
  • Augments HGF-dependent cell scattering and c-Met phosphorylation.
  • Effectively inhibits HGF dimerization at 1 μM.
• In Vivo Studies:
  • Long circulating half-life.
  • Reverses scopolamine-dependent spatial learning deficits.
  • Improves spatial learning in aged rats and induces hippocampal spinogenesis.

Applications:

1. Neurological Research: Investigated as a potential therapeutic agent for Alzheimer's disease and other cognitive disorders.
2. Antipsychotic Development: Evaluated for its role in improving cognitive function and neuroplasticity.
3. Cellular Studies: Ideal for research on HGF signaling pathways, synaptic formation, and neuronal development.

Physical and Chemical Properties:

• Appearance: White Powder
• Purity (HPLC): ≥98.0%
• Acetate Content: 5.0%-12.0%
• Moisture Content: ≤8.0%
• Peptide Content: ≥80.0%
• Amino Acid Composition Analysis: ≤±10%

Storage Information:

• Conditions: Hygroscopic; store in a refrigerator under an inert atmosphere to maintain stability.

Features:

• High Purity: Ensures reliability in research applications.
• Blood-Brain Barrier Permeable: Suitable for neurological studies requiring CNS activity.
• Procognitive Activity: Potential for therapeutic exploration in neurodegenerative diseases.

For further information or to discuss specific requirements, please contact us.