| Customization: | Available |
|---|---|
| CAS No.: | 104987-11-3 |
| Formula: | C44h69no12 |
|
Still deciding? Get samples of US$ 100/g
Request Sample
|
Suppliers with verified business licenses
Audited Supplier Audited by an independent third-party inspection agency
Product Name: Tacrolimus
CAS: 104987-11-3
Appearance: White Powder
Purity: 99% USP 40
Certificates: ISO9001:2015; GMP
Overview
Tacrolimus is a macrolide antibiotic with potent immunosuppressive effects, widely used in preventing organ transplant rejection and treating autoimmune diseases. It works by inhibiting calcineurin phosphatase, suppressing T-cell activation and cytokine production. Compared to cyclosporine, tacrolimus offers stronger immunosuppressive effects with fewer side effects. In daily life, tacrolimus can also be used to treat moderate to severe atopic dermatitis in cases where the immune system is not compromised.
Mechanism of Action
Tacrolimus binds to FKBP-12 within T-cells, forming a complex that inhibits calcineurin activation. This suppression prevents interleukin-2 (IL-2) synthesis and T-cell infiltration into grafts, effectively reducing rejection risk. Its superior graft survival rates, better tolerance, and lower rejection incidence have made it a cornerstone in organ transplantation.
The research team used synthetic biology technology to reconstruct the production bacteria and fermentation process for precise optimization, and obtained high-yield and stable production bacteria; The separation and purification process has been restructured, and impurities of homologous substances have been basically eliminated. The total impurities of the raw material are far below 1.0%, meeting the USP-40 standard. The project has been granted multiple domestic and foreign invention patents and has independent intellectual property rights.
){kind=link}