Factory Supply 3- (2, 4-dimethoxybenzylidene) Anabaseine/Gts-21 (DMXB-A) CAS 156223-05-1

• Customization: Available
• CAS No.: 156223-05-1
• Formula: C19h22cl2n2o2
• Model NO.: Worldyang
• Environmental Protection: Yes
• Certification: ISO9001
• Color: White
• Classification: Neurotoxin
• Function: Keeping Health and Promoting Growth
• Appearance: Powder
• Melting Point: 216-217 Celsius Degree
• Storage: 2-8 Celsius Degree
• Solubility: >5mg/Ml in Water
• Transport Package: as Required
• Specification: 99%+
• Trademark: Worldyang
• Origin: China
• HS Code: 2933360000

Product Description

Product Name: 3-(2,4-Dimethoxybenzylidene)anabaseine (GTS-21, DMXB-A)
CAS Number: 156223-05-1
Appearance: White Powder
Purity: 99%

Product Description:

3-(2,4-Dimethoxybenzylidene)anabaseine, also known as GTS-21 (DMXB-A), is a selective α7 nicotinic acetylcholine receptor (α7-nAChR) agonist with additional antagonistic activity on α4β2 nAChR (Ki = 20 nM) and 5-HT3A receptors (IC50 = 3.1 μM). This compound has been widely studied for its anti-inflammatory and cognitive-enhancing properties, making it a valuable tool in neuroscience and therapeutic research.

Biological Activity:

• Target Affinity:
  • α7-nAChR: Selective agonist.
  • α4β2 nAChR: High-affinity antagonist (Ki = 20 nM).
  • 5-HT3A Receptor: Antagonist (IC50 = 3.1 μM).
• Mechanism of Action:
  • Activates α7-nAChR to promote anti-inflammatory responses and cognitive enhancement.
  • Inhibits 5-HT3A receptor activity, potentially contributing to its neuroprotective effects.

In Vitro Studies:

• Binds to human α4β2 nAChR with 100-fold higher potency than to human α7-nAChR.
• Demonstrates differential potency compared to (-)-nicotine, with 18-fold and 2-fold reduced activity at α4β2 and α7 nAChRs, respectively.

In Vivo Studies:

• Animal Model: C57BL/6 mice irradiated with 12 Gy to induce radiation-induced lung injury (RILI).
• Dosage: 4 mg/kg administered intraperitoneally on days 1, 3, 7, 14, and 21.
• Results:
  • Reduced pulmonary inflammatory infiltrate and fibrosis in radiation-treated mice.
  • Demonstrated protective effects against radiation-induced lung injury.

Applications:

1. Neuroscience Research: Investigated for its role in enhancing cognition and protecting against neuroinflammation.
2. Therapeutic Development: Potential applications in treating cognitive deficits and inflammatory conditions.
3. Radiation Injury Studies: Shown to mitigate radiation-induced tissue damage, making it a candidate for further studies in protective therapeutics.

Storage Information:

• Conditions: Store at 2-8°C in a tightly sealed container to ensure product stability.

Features:

• High Purity: Ensures reliability in experimental outcomes.
• Selective Activity: Effective for targeted research applications in neuroscience and inflammation.
• Versatile Research Tool: Applicable in cognitive, anti-inflammatory, and radioprotection studies.

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