Factory Supply High Quality Way200070 CAS 440122-66-7 for Anti-Hair Loss

• Customization: Available
• Classification: Biochemical Reagents
• Grade: AR
• Model NO.: Worldyang
• Specific Usage: For Biological Purpose, For Microbiological, Pratical Use, For Synthesis
• Content: Standard
• Usage: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents
• Habit Appellation: Fine Chemicals
• Application: Scientific Research, Health
• Property: Biochemical Reagent
• Boiling Point: 428-498 Celsius Degree
• Solubility: DMSO: Min20 Mg/Ml
• Pka: 7.26
• Density: 1.720 g/cm3
• Storage: at Room Temperature
• Transport Package: as Required
• Specification: 99%+
• Trademark: Worldyang
• Origin: China

Product Description

Product Name: WAY-200070
Chemical Name: 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
CAS Number: 440122-66-7
Appearance: White Powder
Purity: 99%

Product Description:

WAY-200070 is a selective agonist for the estrogen-related receptor beta (ERRβ), with an IC50 of 2.3 nM. It exhibits a significantly lower affinity for ERRα (IC50 = 155 nM), making it a highly specific tool for studying ERRβ-mediated pathways.

Applications:

1. Neuroscience Research:
   • Demonstrates antidepressant-like effects by increasing dopamine levels in the striatum of wild-type mice and reducing immobility in behavioral tests.
2. Behavioral Studies:
   • Enhances agonistic behaviors in male and female mice, including pushing and aggressive grooming.
   • In ovariectomized (OVX) mice, WAY-200070 promotes social learning and preference behaviors.
3. Anxiety and Depression Research:
   • Reduces anxiety-like behaviors in the open-field and elevated plus maze tests.
   • Significantly lowers depressive-like behaviors in the forced swim test.
4. Endocrinology Studies:
   • Useful for exploring estrogen receptor beta functions and associated signaling pathways.

Mechanism of Action:

• Selective Activation of ERRβ:
  • WAY-200070 binds to ERRβ with high selectivity (IC50 = 2.3 nM), inducing nuclear translocation of the receptor and downstream signaling events.

Features:

• High Selectivity: Targets ERRβ with minimal off-target activity.
• Behavioral Modulation: Proven to influence social, cognitive, and emotional behaviors in animal models.
• Versatility: Suitable for a wide range of research applications, including neuroscience, endocrinology, and behavioral science.

In Vivo Studies:

• Dopamine Modulation: A delayed 50% increase in dopamine levels was observed in the striatum following subcutaneous administration (30 mg/kg) in wild-type mice.
• Anxiety and Depression Reduction: Significant anxiolytic and antidepressant-like effects were recorded in behavioral tests.

Storage Information:

• Store at room temperature in a tightly sealed container, protected from moisture and light to ensure stability.

This product is intended for research purposes only and is not for human or veterinary use. For technical support or bulk inquiries, please contact us.