Factory Supply High Quality Way316606 CAS 915759-45-4 for Anti-Hair Loss

• Customization: Available
• CAS No.: 915759-45-4
• Formula: C18h19f3n2o4s2
• Model NO.: Worldyang
• EINECS: 1592732-453-0
• Classification: Biochemical Reagents
• Grade: AR
• Specific Usage: For Biological Purpose, For Microbiological, Pratical Use, For Synthesis
• Content: Standard
• Usage: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents
• Source: Synthesis
• Habit Appellation: Fine Chemicals
• Application: Scientific Research, Health
• Property: Biochemical Reagent
• Boiling Point: 536-666 Celsius Degree
• Solubility: DMSO: 3 Mg/Ml; DMF: 3mg/Ml
• Pka: 8.76
• Density: 1.5 g/cm3
• Transport Package: as Required
• Specification: 99%+
• Trademark: Worldyang
• Origin: China

Product Description

Product Name: WAY-316606
Chemical Name: 5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)-
CAS Number: 915759-45-4
Appearance: White Powder
Purity: 99%

 

Product Description:

WAY-316606 is a highly specific antagonist of Secreted Frizzled-Related Protein 1 (SFRP1). It is known to activate the canonical Wnt/β-catenin signaling pathway in human hair follicles and has been shown to enhance bone formation, making it a promising compound for research in hair growth and bone regeneration.

 

Applications:

1. Hair Growth Research:

   • Stimulates Wnt/β-catenin signaling in human hair follicles, a pathway critical for hair follicle regeneration and growth.

2. Bone Regeneration Studies:

   • Promotes significant bone formation in preclinical models, increasing bone area up to 60% in a dose-dependent manner.

3. Wnt Pathway Studies:

   • Serves as a tool compound to investigate the biological roles of SFRP1 and Wnt/β-catenin signaling in various tissues.

 

Mechanism of Action:

• WAY-316606 selectively binds to SFRP1 (KD = 0.08 µM), inhibiting its function and thereby releasing the inhibition on the Wnt/β-catenin pathway.
• It has a high affinity for SFRP1 (EC50 = 0.65 µM) but exhibits weaker binding to SFRP2 (KD = 1 µM).
• By inhibiting SFRP1, WAY-316606 enhances Wnt signaling, leading to effects such as increased bone formation and hair follicle activation.

 

In Vitro Studies:

• Demonstrates EC50 = 0.65 µM for Wnt-Luciferase activity in U2-OS cells.
• Effective in a fluorescence polarization binding assay, with IC50 = 0.5 µM for competitive binding to SFRP1.

 

In Vivo Studies:

• In neonatal murine calvarial assays, WAY-316606 increases bone area by up to 60%, with an EC50 of approximately 1 nM.
• In female Sprague-Dawley rats, it exhibits:
  • High plasma clearance (77 mL/min/kg).
  • Good solubility and stability in liver microsomes (t1/2 > 60 min in both rat and human species).
  • Rapid decline in plasma exposure after intravenous administration at 2 mg/kg.

 

Features:

• High Specificity: Targets SFRP1 with strong selectivity.
• Bone and Hair Applications: Relevant for both regenerative medicine and dermatological research.
• Stability: Exhibits good aqueous solubility and metabolic stability.

 

Storage Information:

• Store at room temperature in a sealed container. Protect from moisture and light to maintain stability.

 

This product is intended for research purposes only and is not for human or veterinary use. For technical support or bulk inquiries, please contact us.