Factory Supply Isrib (trans-isoMer) CAS 1597403-47-8 as Brain Health Supplements

• Customization: Available
• CAS No.: 1597403-47-8
• Formula: C22h24cl2n2o4
• Model NO.: Worldyang
• Classification: Biochemical Reagents
• Grade: AR
• Specific Usage: For Biological Purpose, For Microbiological, For Microscopic Purpose, Pratical Use, For Synthesis
• Content: Standard
• Usage: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents
• Source: Extract Natural Things
• Habit Appellation: Fine Chemicals
• Application: Scientific Research, Health
• Property: Biochemical Reagent
• Boiling Point: 659-779 Celsius Degree
• Storage: 2-8 Celsius Degree
• Solubility: ≥8.96 Mg/Ml in DMSO
• Pka: 13.63
• Transport Package: as Required
• Specification: 99%+
• Trademark: Worldyang
• Origin: China

Product Description

Product Name: ISRIB (trans-Isomer)
CAS Number: 1597403-47-8
Appearance: White Powder
Purity: 99%

Product Description:

ISRIB (trans-isomer) is a highly selective inhibitor of PERK (PKR-like endoplasmic reticulum kinase), with an IC50 of 5 nM. It is a promising compound for research into cellular stress responses, memory enhancement, and therapeutic applications targeting unfolded protein response (UPR) pathways.

Biological Activity:

• Mechanism:
  • ISRIB inhibits PERK signaling by suppressing eIF2α phosphorylation and its downstream effects, including ATF4 expression, without significantly affecting XBP1s mRNA splicing or XBP1s protein expression.
  • It targets the Integrated Stress Response (ISR) by modulating translation and stress granule assembly.
• Key Metrics:
  • Target: PERK (IC50 = 5 nM in a cell-free assay).

In Vitro Studies:

• ISRIB effectively inhibits endogenous ATF4 expression, reducing cellular survival rates under endoplasmic reticulum (ER) stress.
• Maintains XBP1s mRNA and protein levels, indicating selective inhibition of the PERK pathway.

In Vivo Studies:

• ISRIB exhibits favorable pharmacokinetic properties and good bioavailability in vivo.
• Animal Model: Mice injected intraperitoneally (0.25 mg/kg).
• Results:
  • Enhances spatial and fear memory, improving long-term memory formation.
  • Demonstrates potential in modulating cognitive functions and stress response pathways.

Applications:

1. Neuroscience Research: Enhances memory and studies cellular responses to ER stress.
2. Molecular Biology: Investigates the Integrated Stress Response (ISR) and unfolded protein response (UPR).
3. Drug Development: Serves as a tool for developing PERK-related therapeutics.

Features:

• High Selectivity: Specifically inhibits PERK with minimal off-target effects.
• Versatile Research Uses: Applicable in memory studies, stress pathway modulation, and therapeutic development.
• Potent Activity: Demonstrates efficacy at nanomolar concentrations.

Storage Information:

• Conditions: Store at 2-8°C in a sealed container. Protect from moisture and air to maintain product stability.

Safety and Handling:

• This product is intended for research purposes only. Not for human or veterinary use.

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