Factory Supply Weight Loss Nutrition/Anti-Aging Urolithin a CAS 1143-70-0

• Customization: Available
• CAS No.: 1143-70-0
• Formula: C13h8o4
• Model NO.: Worldyang
• EINECS: 1592732-453-0
• Classification: Biochemical Reagents
• Grade: AR
• Specific Usage: For Biological Purpose, For Microbiological, Pratical Use, For Synthesis
• Content: Standard
• Usage: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents
• Source: Synthesis
• Habit Appellation: Fine Chemicals
• Application: Scientific Research, Health
• Property: Biochemical Reagent
• Melting Point: 340-345 Celsius Degree
• Solubility: Soluble in DMSO(Slightly)
• Density: 1.516 g/cm3
• Pka: 9.07
• Storage: 2-8 Celsius Degree
• Transport Package: as Required
• Specification: 99%
• Trademark: Worldyang
• Origin: China

Product Description

Product Introduction: Urolithin A

Chemical Name: 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
CAS Number: 1143-70-0
Appearance: Light yellow powder
Storage Conditions: 2-8°C

 

Description:
Urolithin A is a metabolite derived from ellagic acid, found naturally in pomegranates and other fruits. Research suggests it may slow certain aging processes by improving mitochondrial function without posing risks to human health. Uniquely, Urolithin A stimulates mitochondrial biogenesis in a manner comparable to regular exercise, making it the only known compound to restore defective mitochondria recycling through autophagy.

 

Physicochemical Properties:

• Soluble in highly polar organic solvents like DMSO and N,N-dimethylformamide (DMF).
• Poor solubility in non-polar solvents like petroleum ether and diethyl ether, as well as in water.

 

Biological Activity:
Urolithin A exhibits anti-inflammatory, antiproliferative, and antioxidant properties. It induces autophagy and apoptosis, inhibits cell cycle progression, and suppresses DNA synthesis in various human cancer cell lines. Key effects include:

• In Vitro Studies:

  • Promotes autophagy and apoptosis in colorectal cancer (SW620) cells.
  • Exerts antiproliferative effects on T24 and Caco-2 cells, with IC50 values of 43.9 μM and 49 μM, respectively.
  • Arrests cell cycle progression at G2/M and S phases in a dose- and time-dependent manner.
  • Enhances protein expression of p53, p38-MAPK, and caspase-3 while suppressing NF-κB and inflammatory mediators.

• In Vivo Studies:

  • Reduces paw edema in treated mice within 1 hour of oral administration.
  • Enhances plasma oxygen radical antioxidant capacity (ORAC) scores, with high levels of the unconjugated compound detected in plasma after administration.

 

Applications:

• Pharmaceutical Research:
  • Development of anti-aging and mitochondrial health supplements.
  • Investigation into anticancer therapies targeting cell proliferation and apoptosis.
• Nutraceuticals:
  • Functional foods and supplements promoting cellular health and oxidative stress reduction.

 

Features and Benefits:

• Anti-Aging Potential: Improves mitochondrial function and biogenesis.
• Cancer Research Applications: Exhibits potent antiproliferative activity and cell apoptosis induction.
• Natural and Safe: Derived from ellagic acid metabolism with proven safety in studies.

 

Packaging and Delivery:

• Supplied in secure, light-resistant containers to maintain stability.
• Customized packaging options available to meet research and industrial needs.

 

Safety and Handling:

• Store at 2-8°C in a dry, sealed container.
• Handle with appropriate personal protective equipment (PPE).

 

Urolithin A is a breakthrough compound for advanced research in aging, mitochondrial health, and oncology. Contact us today for more details or to place an order!