| Certification: | ISO |
|---|---|
| Assay Method: | HPLC |
| Application Form: | Injection, Lotion, Suppository, Capsule |
| Application: | Food, Health Care Products |
| State: | Powder |
| Extract Source: | Fruit and Leaf |
| Samples: |
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| Customization: |
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Suppliers with verified business licenses
Audited Supplier | Product Name | (+)-Camptothecin |
| CAS No. | 7689-03-4 |
| Appearance | yellow powder |
| Purity | 99.0% |
| impurities | ≤0.1% |
| Packing | 220kg/drum; |
| Delivery Time | 2-15 days |
| Storage | Dry and cool place and keep sealed away from strong light |
| Place of Origin | China |
| Customs | Free of customs (door to door) |
| Sample | Available |
| Shelf life | 2 years |
| Payment | T/T,BTC,WU,Credit Card (Safe delivery door to door) |
Quick Details
Type:Other
Form:Powder
Part:Fruit and leaf
Extraction Type:Solvent Extraction
Grade:AAAAA
Model Number:Botanical Extract
Product Name:Acuminata Extract
Test Method:HPLC TLC
Appearance:white powder
Assay:HPLC 10%-99%
Camptothecin is an alkaloid derived from the chinese tree Camptotheca acuminata Decne.
Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I,
by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately
causes tumor cell death. In clinical it is widely believed that camptothecin analogs exhibited
remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication,
it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes.
If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein
cannot be synthesized, it ultimately causes cell death. Application of
camptothecin in clinic is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous
therapy such as topotecan and irinotecan while others have been obtained satisfying
curative effects in clinic.
1) Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I,
by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately
causes tumor cell death.
2) In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication,
it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes.
If the chromosomes cannot be unwound, transcription of DNA message cannot occur and
the protein cannot be synthesized, it ultimately causes cell death.
3) Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility. 4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy
such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.
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Audited Supplier 
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