Factory Supply Weight Loss Nutrition Jbsnf-000088/6-Methoxynicotinamide CAS 7150-23-4 in Stock

• Customization: Available
• CAS No.: 1139-83-9
• Formula: C13h8o3
• Model NO.: Worldyang
• Classification: Biochemical Reagents
• Grade: AR
• Specific Usage: For Biological Purpose, For Microbiological, Pratical Use, For Synthesis
• Content: Standard
• Usage: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents
• Source: Synthesis
• Habit Appellation: Fine Chemicals
• Application: Scientific Research, Health
• Property: Biochemical Reagent
• Melting Point: 178-180 Celsius Degree
• Boiling Point: 279.6-323.6 Celsius Degree
• Solubility: Soluble in DMSO
• Density: 1.213 g/cm3
• Pka: 15.17
• Storage: -20 Celsius Degree
• Transport Package: as Required
• Specification: 99%
• Trademark: Worldyang
• Origin: China

Product Description

Product Introduction: JBSNF-000088 (6-Methoxynicotinamide)

• CAS Number: 7150-23-4
• Appearance: White powder
• Storage Conditions: -20°C

 

Description:
JBSNF-000088 (6-Methoxynicotinamide) is a nicotinamide (NA) analog and a potent inhibitor of Nicotinamide N-methyltransferase (NNMT). It exhibits strong inhibitory activity against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT) with IC50 values of 1.8 µM, 2.8 µM, and 5.0 µM, respectively. This compound is recognized for its significant role in regulating metabolism and has potential applications in weight loss therapies.

 

Biological Activity:

• Targets and Potency:

  • hNNMT (Cell-free assay): IC50= 1.8 µM
  • mkNNMT (Cell-free assay): IC50= 2.8 µM
  • mNNMT (Cell-free assay): IC50= 5.0 µM

• In Vitro Studies:

  • IC50values: 1.6 µM (U2OS cells) and 6.3 µM (differentiated 3T3L1 cells).

• In Vivo Studies:

  • Model: High-fat diet (HFD)-induced obese mice.
  • Dosage: 50 mg/kg (oral, twice daily for 4 weeks).
  • Results:
    • Significant reduction in body weight (%) and fed blood glucose by day 21.
    • Improved oral glucose tolerance with normalization by day 28.

• Pharmacokinetics:

  • Intravenous Administration:
    • Plasma clearance: 21 mL/min/kg.
    • Volume of distribution: 0.7 L/kg.
    • Half-life: 0.5 hours.
  • Oral Administration (10 mg/kg):
    • Cmax: 3568 ng/mL, Tmax: 0.5 hours.
    • Half-life: 0.4 hours.
    • Oral bioavailability: ~40%.

 

Applications:

• Metabolic Research:

  • Regulates metabolism and glucose homeostasis.
  • Potential use in weight loss therapies.

• Pharmaceutical Development:

  • Research into NNMT-related metabolic disorders.
  • Development of treatments for obesity and metabolic syndrome.

 

Features and Benefits:

• High Potency: Effective NNMT inhibitor with strong in vivo and in vitro activity.
• Metabolic Benefits: Enhances glucose tolerance and reduces body weight in preclinical studies.
• Pharmacokinetic Profile: Rapid intestinal absorption with moderate bioavailability.

 

Storage Recommendations:

• Store at -20°C in a sealed, moisture-proof container to ensure stability and activity.

 

Packaging and Delivery:

• Supplied in customized quantities for research and development needs.
• Delivered in temperature-controlled conditions to maintain quality.

 

Safety Notes:

• Use appropriate personal protective equipment (PPE) during handling.
• Avoid exposure to moisture and heat.

 

Conclusion:
JBSNF-000088 is a highly potent NNMT inhibitor with broad applications in metabolic research, weight loss, and pharmaceutical development. Contact us for additional information or to place an order!