Factory Supply Fevipiprant CAS 872365-14-5 for Anti-Hair Loss

• Customization: Available
• CAS No.: 872365-14-5
• Formula: C19h17f3n2o4s
• Model NO.: Worldyang
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Industrial
• Colour: White
• Boiling Point: 582.6-692.6 Celsius Degree
• Storage: Sealed in Dry, Store in Freezer, Under -20celsius
• Solubility: DMF:10mg/Ml; DMSO: 10mg/Ml; Etoh: 1mg/Ml
• Pka: 3.33
• Transport Package: as Required
• Specification: 99%+
• Trademark: Worldyang
• Origin: China

Product Description

Product Name: Fevipiprant (NVP-QAW039)
CAS Number: 872365-14-5
Appearance: White Powder
Purity: 99%

Product Description:

Fevipiprant (NVP-QAW039) is a potent and selective prostaglandin D2 receptor 2 (DP2 or CRTh2) antagonist. This orally active compound has been extensively studied for its effectiveness in treating respiratory and dermatological conditions, particularly severe eosinophilic asthma and atopic dermatitis. Fevipiprant shows promising potential in therapeutic research for conditions involving inflammation and immune response dysregulation.

Applications:

1. Asthma Treatment:
   • Fevipiprant is designed for oral use in treating severe eosinophilic asthma, showing significant efficacy in reducing inflammation and improving lung function.
2. Dermatology:
   • Currently under development for treating conditions such as atopic dermatitis due to its anti-inflammatory properties.
3. Hair Loss:
   • Preliminary studies suggest potential use in hair loss treatments, possibly related to its modulatory effects on inflammatory pathways.

Mechanism of Action:

• Target: CRTh2 receptor
• Binding Affinity:
  • KD = 1.1 nM
  • IC50 = 0.44 nM
• Fevipiprant acts as a competitive and reversible antagonist of CRTh2, blocking the effects of prostaglandin D2 (PGD2). This action mitigates the immune response, including eosinophil activation and recruitment, which are critical in conditions like asthma and dermatitis.

Storage Information:

• Conditions: Store at -20°C in a dry, sealed container to maintain stability.

Features:

• High Purity: 99%, ensuring consistent performance in research and therapeutic applications.
• Broad Potential: Effective in respiratory, dermatological, and hair loss-related research.

This product is intended for research purposes only and is not approved for human or veterinary use. For inquiries, bulk orders, or further technical details, please contact us.